Article

Examination of the contribution of Nav1.7 to axonal propagation in nociceptors

2021-03-12

Abstract excerpt

Nav1.7 is a promising drug target for the treatment of pain because individuals with Nav1.7 loss-of-function mutations are insensitive to pain and do not have other serious neurological deficits. However, current peripherally restricted Nav1.7 inhibitors have not performed well in clinical pain trials, which may reflect a lack of understanding of the function of Nav1.7 in the transmission of nociceptive informatio...

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Literature Corpus work: 6dc04013-8339-5c26-9a78-4d18e30152c2
DOI: 10.1101/2021.03.12.435114

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