Article

Exacerbation of a Subset of Behavioral Phenotypes by Early Treatment with AAV FOXG1 Gene Replacement Therapy in a Mouse Model of FOXG1 Syndrome

2025-10-23

Abstract excerpt

<h4>ABSTRACT</h4> FOXG1 syndrome is a severe neurodevelopmental disorder characterized by microcephaly, profound intellectual disability with communication deficits including lack of speech, impaired social interaction, increased anxiety, hyperkinetic/dyskinetic movements, seizures and abnormal sleep patterns. Mutations in a single allele of the FOXG1 gene cause disease, likely due to loss-of-function. However,...

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Literature Corpus work: 6d76312f-0842-536b-b0d4-1e29d341ce53
DOI: 10.1101/2025.10.22.683927

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