Article

Behavioral and imaging analysis of Foxg1 heterozygous mice

2022-03-30

Abstract excerpt

FOXG1 Syndrome (FS) is a devastating neurodevelopmental disorder that is caused by a heterozygous loss-of-function (LOF) mutation of the FOXG1 gene, which encodes a transcriptional regulator important for telencephalic brain development. People with FS have marked developmental delays, impaired ambulation, movement disorders, seizures, and behavior abnormalities including autistic features. Current therapeutic ap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88a828ea-ca7c-5edd-91b8-8f86a2eb9032
DOI: 10.1101/2022.03.29.486318

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Behavioral and imaging analysis of Foxg1 heterozygous miceDOI 10.1101/2022.03.29.486318Read

The patient-specific mouse model with Foxg1 frameshift mutation uncovers the pathophysiology of FOXG1 syndromeSemantic proximity Read

Paving Therapeutic Avenues for FOXG1 Syndrome: Untangling Genotypes and Phenotypes from a Molecular PerspectiveSemantic proximity Read

Paving Therapeutic Avenues for FOXG1 Syndrome: Untangling Genotypes and Phenotypes from a Molecular Perspective.Semantic proximity Read

The patient-specific mouse model with <i>Foxg1</i> frameshift mutation provides insights into the pathophysiology of FOXG1 syndromeSemantic proximity Read

Behavioral Efficacy of AAV FOXG1 Gene Replacement Therapy in a Mouse Model of FOXG1 SyndromeSemantic proximity Read

Integrating molecular studies and clinical disease models to provide mechanistic insight into neurodevelopment: guidance from FOXG1 syndrome.Semantic proximity Read

Exacerbation of a Subset of Behavioral Phenotypes by Early Treatment with AAV FOXG1 Gene Replacement Therapy in a Mouse Model of FOXG1 SyndromeSemantic proximity Read

<i>In-utero</i> rescue of neurological dysfunction in a mouse model of Wiedemann-Steiner syndromeSemantic proximity Read

Human patient-specific FOXG1 syndrome mouse model revealed FOXG1-MYCN-mediated regulation of protein homeostasis in neurodevelopmental disorderSemantic proximity Read

Mouse Models of <i>GNAO1</i> -Associated Movement Disorder: Allele- and sex-specific differences in phenotypesSemantic proximity Read

Morphological and behavioral analysis of Slc35f1-deficient mice revealed no neurodevelopmental phenotype.Semantic proximity Read

Models of Bosch-Boonstra-Schaaf optic atrophy syndrome reveal genotype-phenotype correlations in brain structure and behavior.Semantic proximity Read