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Identification and characterization of functional and trans-dominant negative HERV-K (HML-2) Rec proteins encoded in the human genome

2025-07-07

Abstract excerpt

Human Endogenous Retroviruses K (HERV-K) of the HML-2 subgroup are the most recently integrated and biologically active retroviral elements within the human genome. The HERV-K Rec protein, a functional homolog of HIV Rev and HTLV Rex, is necessary for the nuclear export of viral mRNAs with retained introns. However, the diversity of Rec proteins encoded in the human genome and their functional capacities have rema...

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Literature Corpus work
6d72cb60-25e7-5e41-9fa3-9c041be99c7e
DOI
10.1101/2025.07.07.663474
Open publication

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Identification and characterization of functional and trans-dominant negative HERV-K (HML-2) Rec proteins encoded in the human genomeDOI 10.1101/2025.07.07.663474
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