Article

HERV-K HML-2 transcription in diverse cancers is related with cancer stem cell and epithelial-mesenchymal transition markers

2018-10-25

Abstract excerpt

Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections that make up 8% of the human genome. Although these elements are mostly fragmented and inactive, many proviruses belonging to the HERV-K (HML-2) family, the youngest lineage in the human genome, have intact open reading frames, some encoding for accessory genes called np9 and rec that interact with oncogenic pathways. Many studies have...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a81a1725-ae8b-5128-b361-088181c3515e
DOI: 10.1101/451997

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HERV-K HML-2 transcription in diverse cancers is related with cancer stem cell and epithelial-mesenchymal transition markersDOI 10.1101/451997Read

Targeting endogenous retrovirus gene transcription in human cancersSemantic proximity Read

HERV-K(HML-2) rec and np9 transcripts not restricted to disease but present in many normal human tissuesSemantic proximity Read

HERVs and Cancer—A Comprehensive Review of the Relationship of Human Endogenous Retroviruses and Human CancersSemantic proximity Read

Expression of Human Endogenous Retroviruses (HERVs) in Breast Cancer: A Transcriptomic StudySemantic proximity Read

Long Non-coding RNAs: Key Regulators of Tumor Epithelial/Mesenchymal Plasticity and Cancer StemnessSemantic proximity Read

Comprehensive Characterization of the Human Endogenous Retrovirus HERV-K(HML-6) Group: Overview of Structure, Phylogeny, and Contribution to the Human GenomeSemantic proximity Read

HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and DiseaseSemantic proximity Read

The role of endogenous retroviruses‐K in human cancerSemantic proximity Read

Human Endogenous Retrovirus K Rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stageSemantic proximity Read

ERVcancer: a web resource designed for querying activation of human endogenous retroviruses across major cancer typesSemantic proximity Read

Comprehensive identification and characterization of HERV-K (HML-9) group in the human genomeSemantic proximity Read

Expression of young HERV-H loci in the course of colorectal carcinoma and correlation with molecular subtypesSemantic proximity Read