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Article

Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload.

Journal of cardiovascular translational research - 1 Aug 2023

Ramachandran Abhinay, Livingston Carissa E, Vite Alexia, Corbin Elise A, Bennett Alexander I, Turner Kevin T, Lee Benjamin W, Lam Chi Keung, Wu Joseph C, Margulies Kenneth B

Abstract excerpt

Engineered cardiac microtissues were fabricated using pluripotent stem cells with a hypertrophic cardiomyopathy associated c. 2827 C>T; p.R943x truncation variant in myosin binding protein C (MYBPC3+/-). Microtissues were mounted on iron-incorporated cantilevers, allowing manipulations of cantilever stiffness using magnets, enabling examination of how in vitro afterload affects contractility. MYPBC3+/-...

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Identifiers

PMID: 36877449
DOI: 10.1007/s12265-022-10348-4
PMCID: PMC10480352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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