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Article

Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function.

Cell reports - 27 Oct 2015

Birket Matthew J, Ribeiro Marcelo C, Kosmidis Georgios, Ward Dorien, Leitoguinho Ana Rita, van de Pol Vera, Dambrot Cheryl, Devalla Harsha D, Davis Richard P, Mastroberardino Pier G, Atsma Douwe E, Passier Robert, Mummery Christine L

Abstract excerpt

Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac toxicity and disease. Here, we aimed to identify factors that would promote an adequate level of function to permit robust single-cell contractility measurements in a human induced pluripotent stem cell (hiPSC) model of hypertrophic cardiomyopathy (HCM). A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26489474
DOI: 10.1016/j.celrep.2015.09.025
PMCID: PMC4644234

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function.PMID 26489474Read ↗

Cardiomyopathy phenotypes caused by a heterozygous MYBPC3 mutation revealed in different hiPSC cardiac models.Semantic proximity Read ↗

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