Article

Stress, Epigenetic Remodeling and FKBP51: Pathways to Chronic Pain Vulnerability

2025-01-07

Abstract excerpt

Stress is thought to contribute to the persistence of pain and comorbid anxiety, yet the underlying mechanisms remain unclear. In our pre-clinical model, sub-chronic stress exacerbated subsequently induced inflammatory pain and accelerated the development of comorbid anxiety. DNA methylation analysis of spinal cord tissue after stress exposure revealed hypomethylation in the Fkbp5 promoter site for the canonical...

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Literature Corpus work: 6d51fc9f-e93e-5814-856a-afb021c67d23
DOI: 10.1101/2025.01.07.631709

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