Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain

30 Sept 2023

Abstract excerpt

BACKGROUND: Epigenetic changes can bring insight into gene regulatory mechanisms associated with disease pathogenicity, including chronicity and increased vulnerability. To date, we are yet to identify genes sensitive to epigenetic regulation that contribute to the maintenance of chronic pain and with an epigenetic landscape indicative of the susceptibility to persistent pain. Such genes would provide a novel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Pain Management and Opioid Use
Share to Pain Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37777763
DOI: 10.1186/s13148-023-01569-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic painPMID 37777763Read ↗

Using the DNA methylation profile of the stress driver gene <i>FKBP5</i> for chronic pain diagnosisSemantic proximity Read ↗

Stress, Epigenetic Remodeling and FKBP51: Pathways to Chronic Pain VulnerabilitySemantic proximity Read ↗

Does epigenetic ‘memory’ of early-life stress predispose to chronic pain in later life? A potential role for the stress regulator FKBP5Semantic proximity Read ↗

Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptomsSemantic proximity Read ↗

The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signalingSemantic proximity Read ↗

A Functional riboSNitch in the 3' Untranslated Region of FKBP5 Alters MicroRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Post-Traumatic Pain.Semantic proximity Read ↗

Genes and epigenetic processes as prospective pain targetsSemantic proximity Read ↗

Genetic and epigenetic epidemiology of chronic widespread painSemantic proximity Read ↗

Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populationsSemantic proximity Read ↗

Hippocampal volume, FKBP5 genetic risk alleles, and childhood trauma interact to increase vulnerability to chronic multisite musculoskeletal pain.Semantic proximity Read ↗

Childhood traumatization is associated with differences in TRPA1 promoter methylation in female patients with multisomatoform disorder with pain as the leading bodily symptomSemantic proximity Read ↗

Epigenetic Landscapes of Pain: DNA Methylation Dynamics in Chronic PainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.