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Article

Hippocampal volume, FKBP5 genetic risk alleles, and childhood trauma interact to increase vulnerability to chronic multisite musculoskeletal pain.

Scientific reports - 20 Apr 2022

Lobo Jarred J, Ayoub Lizbeth J, Moayedi Massieh, Linnstaedt Sarah D

Abstract excerpt

Chronic multisite musculoskeletal pain (CMP) is common and highly morbid. However, vulnerability factors for CMP are poorly understood. Previous studies have independently shown that both small hippocampal brain volume and genetic risk alleles in a key stress system gene, FKBP5, increase vulnerability for chronic pain. However, little is known regarding the relationship between these factors and CMP. Here we...

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Identifiers

PMID: 35444168
DOI: 10.1038/s41598-022-10411-9
PMCID: PMC9021300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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