Article

Caris-ComBat-seq: Directionally Harmonizing Large-Scale RNA-seq Datasets

2025-12-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Bulk RNA sequencing (RNA-seq) is an essential research and clinical diagnostics tool capable of uncovering biological insights across experimental conditions, sample types and diseases at scale. However, RNA-seq data is sensitive to batch effects introduced by technical variation. Harmonizing expression (or batch-correcting) is critical when analyzing measurements from diffe...

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Literature Corpus work: 6b6d9e17-6aad-5bdd-85e3-e18778f6531f
DOI: 10.1101/2025.11.26.690779

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