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Optimizing bioinformatic workflows to extract clinically usable gene expression data from targeted RNA sequencing panels: comparison with total RNAseq

2026-02-03

Abstract excerpt

<title>Abstract</title> <p>Targeted RNA sequencing (RNAseq) is widely used to detect gene fusions in tumors but clinical diagnostic use of expression data from these panels in fusion-negative cases has been limited. To facilitate this application, we evaluated methods for sequence read counting and gene normalization to optimize them for smaller gene sets. We present comparative methods to derive differential gen...

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Literature Corpus work: 8cec0263-ead1-5b51-80d7-5bfd6486533b
DOI: 10.21203/rs.3.rs-8695099/v1

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