Back to search

Article

Characterization of a GpsB-associated regulator of PBP1a reveals the organization of the cell wall remodeling complex of <i>Streptococcus pneumoniae</i>

2024-11-09

Abstract excerpt

<h4>SUMMARY</h4> Class A PBPs (aPBPs) play a key role in the biosynthesis and remodeling of peptidoglycan, the main component of the bacterial cell wall. The human bacterial pathogen Streptococcus pneumoniae produces three aPBPs, which are regulated to maintain the bacterium’s ovoid shape. Although their exact functions remain unclear, evidence suggests that PBP1a and PBP2a activities are closely coordinated. In...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6d0f4e35-fc05-5f34-ab94-6c3a03757e0f
DOI
10.1101/2024.11.09.622756
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Characterization of a GpsB-associated regulator of PBP1a reveals the organization of the cell wall remodeling complex of <i>Streptococcus pneumoniae</i>DOI 10.1101/2024.11.09.622756
A bacterial cell wall repair and modification system to resist host antibacterial factorsSemantic proximity
Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39.Semantic proximity
Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsX <sub> <i>Spn</i> </sub> cell division protein in <i>Streptococcus pneumoniae</i> D39Semantic proximity
The morphogenic protein CopD controls the spatio-temporal dynamics of PBP1a and PBP2b in Streptococcus pneumoniae.Semantic proximity
Penicillin-Binding Protein 1 (PBP1) of Staphylococcus aureus Has Multiple Essential Functions in Cell DivisionSemantic proximity
Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae.Semantic proximity
Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell of <i>Streptococcus pneumoniae</i>Semantic proximity
PBP1 of <i>Staphylococcus aureus</i> has multiple essential functions in cell divisionSemantic proximity
<i>PgaR</i> is a positive regulator of the <i>pgaABCD</i> biosynthetic operon in <i>Klebsiella pneumoniae</i>Semantic proximity
Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae.Semantic proximity
A CozE Homolog Contributes to Cell Size Homeostasis of Streptococcus pneumoniae.Semantic proximity
Suppression and synthetic-lethal genetic relationships of ΔgpsB mutations indicate that GpsB mediates protein phosphorylation and penicillin-binding protein interactions in Streptococcus pneumoniae D39.Semantic proximity
Select a neighboring publication to make it the new centre.