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Article

The morphogenic protein CopD controls the spatio-temporal dynamics of PBP1a and PBP2b in Streptococcus pneumoniae.

mBio - 31 Oct 2023

Lenoir Cassandra, Pelletier Anaïs, Manuse Sylvie, Millat Hugo, Ducret Adrien, Galinier Anne, Doan Thierry, Grangeasse Christophe

Abstract excerpt

IMPORTANCE: Penicillin-binding proteins (PBPs) are essential for proper bacterial cell division and morphogenesis. The genome of Streptococcus pneumoniae encodes for two class B PBPs (PBP2x and 2b), which are required for the assembly of the peptidoglycan framework and three class A PBPs (PBP1a, 1b and 2a), which remodel the peptidoglycan mesh during cell division. Therefore, their activities should be finely...

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Identifiers

PMID: 37728370
DOI: 10.1128/mbio.01411-23
PMCID: PMC10653890

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