Article

Cell-Type-Resolved Transcriptomics Defines Stable and Accessible Markers of the Cardiac Purkinje Fiber in Sheep and Human Translation

2026-08-25

Abstract excerpt

<h4>Background: </h4> The His-Purkinje network drives rapid ventricular activation and is a major substrate for ventricular arrhythmias, yet it is among the least molecularly characterized cardiac compartments. Markers validated in rodents transfer poorly across species, few are confirmed at the protein level in large mammals or humans, and most lack the stability and surface accessibility that demanding applicati...

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Literature Corpus work: 6d0f2bc7-1ba3-5bab-b487-1feeec9bd6b6
DOI: 10.64898/2026.08.21.746241

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