Structural variation detection of adolescent thyroid cancer using optical mapping

Abstract excerpt

Abstract：Structural variation (SV) is a fundamental genetic cause for cancer, with demonstrated correlation to disease progression and treatment response. Traditional sequencing method cannot provide full genomic landscape especially large-scale and complex structural variation. To overcome these limitations, we adopted a combined sequencing approaches, including optical mapping, single molecular sequencing and sh...

Topics

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• Child
• Chromosome Mapping
• Genetic Predisposition to Disease
• Genome, Human
• Genomic Structural Variation
• Germ-Line Mutation
• Mutation
• Neoplasms

Identifiers and source

Literature Corpus work

6d023f92-f763-5c24-bf69-41124c0f56fd

DOI

10.22541/au.170669371.13812935/v1