Structural Variation Detection of Adolescent Thyroid Cancer Using Optical Mapping

Abstract excerpt

Structural variation (SV) is a fundamental genetic cause for cancer, with demonstrated correlation to disease progression and treatment response. Traditional sequencing method cannot provide full genomic landscape especially large-scale and complex structural variation. To overcome these limitations, we adopted a combined sequencing approaches, including optical mapping, single molecular sequencing and short reads...

Topics

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• Child
• Chromosome Mapping
• Genetic Predisposition to Disease
• Genome, Human
• Genomic Structural Variation
• Germ-Line Mutation
• Mutation
• Neoplasms

Identifiers and source

Literature Corpus work

1ce39e5f-fa2e-58c0-b5bc-8f9837a2d671

DOI

10.21203/rs.3.rs-1172959/v1