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Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions

13 Feb 2023

Abstract excerpt

Triple-negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial-mesenchymal transition (EMT), contributes to self-renewal of cancer stem-like cells (CSCs), chemo-resistance, metastasis, and TNBC-related death. However, the mechanism by which TWIST1 is deregulated in TNBC remains elusive. Here, USP29 is identified as a bona fide...

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PMID: 36782089
DOI: 10.1002/advs.202205873

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