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Article

Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes.

Genes, chromosomes & cancer - 1 Apr 2016

Mertens Fredrik, Antonescu Cristina R, Mitelman Felix

Abstract excerpt

Gene fusions have been described in approximately one-third of soft tissue tumors (STT); of the 142 different fusions that have been reported, more than half are recurrent in the same histologic subtype. These gene fusions constitute pivotal driver mutations, and detailed studies of their cellular effects have provided important knowledge about pathogenetic mechanisms in STT. Furthermore, most fusions are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26684580
DOI: 10.1002/gcc.22335
PMCID: PMC5012284

Genes

ALK
PDGFB
ROS1

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