Article

A comprehensive genomic framework for identifying genes predisposing to homologous recombination repair deficient breast cancer

2025-10-23

Abstract excerpt

<h4>Background</h4> Patients with clinical characteristics of increased cancer susceptibility without an identified genetic lesion are regularly seen in clinics. Case-control studies and matched normal/tumour sequencing have advanced the discovery of Cancer Susceptibility Genes (CSGs), with limitations when used independently. We reasoned that combining these strategies alongside mutational signatures and clinica...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c830cc5-16ef-53b3-953d-b73ea2e7f42e
DOI: 10.1101/2025.10.22.25338181

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A comprehensive genomic framework for identifying genes predisposing to homologous recombination repair deficient breast cancerDOI 10.1101/2025.10.22.25338181Read

Integrative Gene-Centric Analysis of Breast Cancer: High-Confidence Germline Predisposition Genes from Population-Scale CohortsSemantic proximity Read

Disease Spectrum of Breast Cancer Susceptibility GenesSemantic proximity Read

Exome-based cancer driver gene comprehensive testing can provide a genetic diagnosis for individuals with triple-negative breast cancer.Semantic proximity Read

Functions of Breast Cancer Predisposition Genes: Implications for Clinical Management.Semantic proximity Read

Understanding genetic variations associated with familial breast cancer.Semantic proximity Read

<i>Identification and Characterization of Rare Pathogenic</i> Gene <i>tic Variants Associated with Breast Cancer Susceptibility in 1000 Genome and gnomAD Population</i>Semantic proximity Read

Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilitiesSemantic proximity Read

Detection of novel germline mutations for breast cancer in non-BRCA1/2 families.Semantic proximity Read

Integrating breast tumor homologous recombination deficiency status to aid germline<i>BRCA1</i>and<i>BRCA2</i>variant classificationSemantic proximity Read

Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data.Semantic proximity Read

Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classification.Semantic proximity Read

Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles.Semantic proximity Read