Article
Modulation of FLT3-ITD and CDK9 in acute myeloid leukaemia cells by novel proteolysis targeting chimera (PROTAC).
European journal of medicinal chemistry - 5 Dec 2022
Řezníčková Eva, Krajčovičová Soňa, Peřina Miroslav, Kovalová Markéta, Soural Miroslav, Kryštof Vladimír
Abstract excerpt
Oncogenic mutations in gene encoding FLT3 kinase are often detected in acute myeloid leukaemia (AML) patients, and several potent kinase inhibitors have been developed. However, the FLT3 inhibitor treatment often leads to the resistance development and subsequent relapse. Targeted degradation of oncogenic protein kinases has emerged as a feasible pharmacological strategy, providing more robust effect over...
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