Article

FLT3-ITD-Specific PROTAC: Enhanced Safety and Increased Synergy with Venetoclax in Acute Myeloid Leukemia

2023-12-06

Abstract excerpt

<h4>Background: </h4> Patients with acute myeloid leukemia (AML) carrying Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutations often face a poor prognosis, high risk of relapse, and short overall survival. While some FLT3 small molecule inhibitors have been used clinically, challenges such as short efficacy, poor specificity, and resistance persist. Proteolytic targeting chimera (PROTAC), wi...

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Literature Corpus work: 4a6b77d9-2610-5438-a84a-5413c71ff172
DOI: 10.21203/rs.3.rs-3699368/v1

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