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Article

Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins.

Leukemia - 1 Dec 2024

Halilovic Melisa, Abdelsalam Mohamed, Zabkiewicz Joanna, Lazenby Michelle, Alvares Caroline, Schmidt Matthias, Brenner Walburgis, Najafi Sara, Oehme Ina, Hieber Christoph, Zeyn Yanira, Bros Matthias, Sippl Wolfgang, Krämer Oliver H

Abstract excerpt

Internal tandem duplications in the FMS-like tyrosine kinase-3 (FLT3-ITD) are common mutations in acute myeloid leukemia (AML). Proteolysis-targeting chimeras (PROTACs) that induce proteasomal degradation of mutated FLT3 emerge as innovative pharmacological approach. Molecular mechanisms that control targeted proteolysis beyond the ubiquitin-proteasome-system are undefined and PROTACs are the only known type of...

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Identifiers

PMID: 39300221
DOI: 10.1038/s41375-024-02405-5
PMCID: PMC11588663

Genes

FLT3
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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