Article

Attenuated Asthma Phenotype in Mice With a Fetal-Like Antigen Receptor Repertoires

2021-01-07

Abstract excerpt

We hypothesized that the scarcity of N-nucleotides might contribute to the inability of the neonate to mount a robust allergic immune response. To test this, we used terminal deoxyribunucleotidyl Transferase deficient (TdT-/-) mice, which express “fetal like” T cell receptor and immunoglobulin repertoires with largely germline-encoded CDR3 regions.Intraperitoneal sensitization was followed by aerosol provocation w...

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Literature Corpus work: 6c449145-f81a-50aa-9d9f-067330a16564
DOI: 10.21203/rs.3.rs-130541/v1

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