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Article

Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.

Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1992

Bogue M, Gilfillan S, Benoist C, Mathis D

Abstract excerpt

The random addition of "N nucleotides" by terminal deoxynucleotidyltransferase (TdT) is an important component of the diversity of T-cell receptor genes. We have investigated the expression of TdT during thymocyte differentiation and thymus ontogeny. TdT gene transcripts are confined to immature thymocytes of the cortex, being down-regulated concomitantly with recombination-activating gene transcripts after...

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Identifiers

PMID: 1438306
DOI: 10.1073/pnas.89.22.11011
PMCID: PMC50473

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