Article
Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1992
Bogue M, Gilfillan S, Benoist C, Mathis D
Abstract excerpt
The random addition of "N nucleotides" by terminal deoxynucleotidyltransferase (TdT) is an important component of the diversity of T-cell receptor genes. We have investigated the expression of TdT during thymocyte differentiation and thymus ontogeny. TdT gene transcripts are confined to immature...
Topics
- Aging
- Animals
- Animals, Newborn
- Base Sequence
- Cell Differentiation
- DNA Nucleotidylexotransferase
- Exons
- Gene Expression Regulation
- Genetic Variation
- Heart
- Homeodomain Proteins
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Proteins
- RNA, Messenger