Article

Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced Neurotoxicity

2025-04-26

Abstract excerpt

<h4>Background</h4> General anesthetics have been shown to cause acute pathological changes in the developing brain, including neuronal cell death. These effects contribute to long-term cognitive and behavioral impairments observed in animal models. Epidemiological and prospective clinical studies have also reported associations between early-life exposure to anesthesia and neurodevelopmental deficits in children...

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Literature Corpus work: 6c346b21-85d6-5663-ae5f-54c34cfc8ae8
DOI: 10.1101/2025.04.23.650256

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