Article
Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice.
Endocrinology - 1 Oct 2015
Pollock Kelly E, Stevens Damaiyah, Pennington Kathleen A, Thaisrivongs Rose, Kaiser Jennifer, Ellersieck Mark R, Miller Dennis K, Schulz Laura Clamon
Abstract excerpt
Pregnant women who are obese or have gestational diabetes mellitus have elevated leptin levels and their children have an increased risk for child and adult obesity. The goals of this study were to determine whether offspring weights are altered by maternal hyperleptinemia, and whether this occurs via behavioral changes that influence energy balance. We used 2 hyperleptinemic mouse models. The first was females...
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