Article

Irradiated mesenchymal stromal cells induce genetic instability in human CD34+ cells

2020-10-30

Abstract excerpt

Radiation-induced bystander effects (RIBE) in human hematopoietic stem and progenitor cells may initiate myeloid neoplasms (MN). Here, the occurrence of RIBE caused by genotoxic signaling from irradiated human mesenchymal stromal cells (MSC) on human bone marrow CD34+ cells was investigated. For this purpose, healthy MSC were irradiated in order to generate conditioned medium containing potential genotoxic signali...

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Literature Corpus work: 6c132f95-7807-5168-9926-392818fef7dd
DOI: 10.1101/2020.10.30.361758

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