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Article

Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or γ-irradiation

1 Nov 2011

Abstract excerpt

DNA damaging agents are widely used in treatment of hematogical malignancies and solid tumors. While effects on hematopoietic stem cells have been characterized, less is known about the DNA damage response in human mesenchymal stem cells (hMSCs) in the bone marrow stroma, progenitors of osteoblasts, chondrocytes and adipocytes. To elucidate the response of undifferentiated hMSCs to γ-irradiation and cisplatin,...

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PMID: 22037398
DOI: 10.4161/cc.10.21.17972

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