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Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage

22 Apr 2021

Abstract excerpt

Total body irradiation (TBI) is commonly used in host conditioning regimens for human hematopoietic stem cell (HSC) transplantation to treat various hematological disorders. Exposure to TBI not only induces acute myelosuppression and immunosuppression, but also injures the various components of the HSC niche in recipients. Our previous study demonstrated that radiation-induced bystander effects (RIBE) of...

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PMID: 33881475
DOI: 10.1182/blood.2020007362

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