Article

Exploring protein orthogonality in immune space: a case study with AAV and Cas9 orthologs

2018-01-10

Abstract excerpt

<h4>ABSTRACT</h4> A major hurdle in protein-based therapeutics is the interaction with the adaptive immune system, which can lead to neutralization by circulating antibodies and clearance of treated cells by cytotoxic T-lymphocytes. One method of circumventing these issues is to use human or humanized proteins which avoid the immune response by self-recognition. However, this approach limits potential protein the...

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Literature Corpus work: 6be94f7f-af63-5c75-9f80-eae83b4a8632
DOI: 10.1101/245985

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