Four classic “de novo” genes all have plausible homologs and likely evolved from retro-duplicated or pseudogenic sequences

Abstract excerpt

<title>Abstract</title> <p>Despite being previously regarded as extremely unlikely, the idea that entirely novel protein-coding genes can emerge from non-coding sequences has gradually become accepted over the past two decades. Examples of “de novo origination”, resulting in lineage-specific “orphan” genes, lacking orthologs, are now produced every year. However, many are likely cases of duplicates that are diffi...

Topics

Open a Topic to create a Post that cites this publication.

• Evolution, Molecular
• Genome, Human
• Introns
• Pseudogenes
• RNA Stability
• RNA, Untranslated
• Segmental Duplications, Genomic
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

6bc92443-4e3e-56c9-83cd-9ae15c56bc9e

DOI

10.21203/rs.3.rs-2996044/v2