Article

Predicting vaccine effectiveness in Mpox

2023-11-24

Abstract excerpt

The Modified Vaccinia Ankara vaccine developed by Bavarian Nordic (MVA-BN) was widely deployed to prevent Mpox during the 2022 global outbreak. This vaccine was initially approved for Mpox based on its reported immunogenicity and effectiveness in animal models, rather than evidence of clinical efficacy. However no validated correlate of protection after vaccination has been identified. Here we performed a systemat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ba7752f-c9cb-5f4e-97f3-df71fa15fc01
DOI: 10.1101/2023.11.23.23298850

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predicting vaccine effectiveness in MpoxDOI 10.1101/2023.11.23.23298850Read

Real-world effectiveness of mpox (monkeypox) vaccines: a systematic reviewSemantic proximity Read

Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primatesSemantic proximity Read

Low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individualsSemantic proximity Read

Complement-dependent mpox virus-neutralizing antibodies in infected and vaccinated individualsSemantic proximity Read

Single-dose Efficacy of a Next-Generation Mpox Vaccine Harnessing an Immunomodulatory PeptideSemantic proximity Read

Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpoxSemantic proximity Read

Monkeypox Virus and Vaccinia Vaccines: Genomic and Antigenic Differences Relevant to Outbreaks and VaccinologySemantic proximity Read

Systematic evaluation of the induction of efficient neutralizing antibodies by recombinant multicomponent subunit vaccines against monkeypox virusSemantic proximity Read

Mpox vaccine and infection-driven human immune signaturesSemantic proximity Read

Effectiveness of one dose of MVA-BN smallpox vaccine against monkeypox in England using the case-coverage methodSemantic proximity Read

Monkeypox virus-neutralising antibodies detected against Clade Ib and Clade IIb in healthy individuals following MVA-BN vaccinationSemantic proximity Read

Two noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infectionsSemantic proximity Read