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Article

Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpox

15 Apr 2025

Abstract excerpt

BACKGROUND: The global mpox outbreak (2022-2024) highlights the need for effective and safe vaccines, particularly for vulnerable populations. The LC16m8 vaccine, an attenuated vaccinia virus strain for smallpox, shows promise in inducing immunity against the monkeypox virus (MPXV). METHODS: We conducted a comprehensive immunological evaluation of LC16m8 in mice, non-human primates, and humans. FINDINGS: LC16m8...

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PMID: 40239465
DOI: 10.1016/j.ebiom.2025.105703

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