Monkeypox Virus and Vaccinia Vaccines: Genomic and Antigenic Differences Relevant to Outbreaks and Vaccinology

Abstract excerpt

Amid the current multi-country mpox outbreak, analyzing monkeypox virus (MPXV) and vaccinia virus (VACV) genomes is vital for understanding evolutionary processes that may impact vaccine efficacy and design. This study aimed to elucidate the phylogenetic relationships and structural features of viral antigens, which are crucial for developing effective vaccines. By aligning 1,903 MPXV genomes from the NCBI Virus r...

Topics

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• Bacillus and Francisella bacterial research
• Genomics
• Herpesvirus Infections and Treatments
• Mutation
• Phylogeny
• Poxvirus research and outbreaks
• Transgenic Plants and Applications
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

0eb6e99a-39d0-5f99-9991-7dc20660a945

DOI

10.20944/preprints202410.2082.v1