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Article

Hepatic spheroids used as an in vitro model to study malaria relapse

22 May 2019

Abstract excerpt

Hypnozoites are the liver stage non-dividing form of the malaria parasite that are responsible for relapse and acts as a natural reservoir for human malaria Plasmodium vivax and P. ovale as well as a phylogenetically related simian malaria P. cynomolgi. Our understanding of hypnozoite biology remains limited due to the technical challenge of requiring the use of primary hepatocytes and the lack of robust and...

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PMID: 31195301
DOI: 10.1016/j.biomaterials.2019.05.032

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