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Copper Induces Zebrafish Central Neural System Myelin Defects: the Regulatory Mechanisms in Wnt/Notch- <i>hoxb5b</i> Signaling and Underlying DNA Methylation

2019-12-16

Abstract excerpt

Unbalanced copper (Cu 2+ ) homeostasis is associated with neurological development defects and diseases. However, the molecular mechanisms remain elusive. Here, central neural system (CNS) myelin defects and down-regulated expression of Wnt/Notch signaling and their down-stream mediator hoxb5b were observed in Cu 2+ stressed zebrafish larvae. Loss/knockdown-of-function of hoxb5b phenocopied the myelin and axon...

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Literature Corpus work
6b89ea9a-7a5b-5dfe-b45b-9bc37793155b
DOI
10.1101/2019.12.16.877860
Open publication

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Copper Induces Zebrafish Central Neural System Myelin Defects: the Regulatory Mechanisms in Wnt/Notch- <i>hoxb5b</i> Signaling and Underlying DNA MethylationDOI 10.1101/2019.12.16.877860
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