Article

Integration of epigenomic and transcriptome analyses of neural tube defects reveals methylation driver lncRNAs and mRNAs

2022-10-28

Abstract excerpt

<h4>Background: </h4> Abnormal genome-wide methylation during embryogenesis is associated with neural tube defects (NTDs) at birth. Long noncoding RNAs (lncRNAs) may be promising biomarkers for nervous system-related diseases. Therefore, we aimed to investigate the role of lncRNAs with aberrant methylation in the pathogenesis of NTDs. Methods Pregnant mice were given retinoic acid (dissolved in corn oil, 50 mg/kg...

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Literature Corpus work: 039b9593-96cd-5d10-a180-2a4252451fd0
DOI: 10.21203/rs.3.rs-2197744/v1

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