Article
Qualitative and quantitative top-down proteomics of human colorectal cancer cell lines identified 23000 proteoforms and revealed drastic proteoform-level differences between metastatic and non-metastatic cancer cells
2021-10-28
Abstract excerpt
Understanding cancer metastasis at the proteoform level is crucial for discovering new protein biomarkers for cancer diagnosis and drug development. Proteins are the primary effectors of function in biology and proteoforms from the same gene can have drastically different biological functions. Here, we present the first qualitative and quantitative top-down proteomics (TDP) study of a pair of isogenic human metast...
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Identifiers and source
- Literature Corpus work
- 6b870a99-52c0-52f3-9621-9bcc90ff2873
- DOI
- 10.1101/2021.10.27.466093