Article
Proteomic Landscape of Colorectal Cancer Derived Liver Metastasis Reveals Three Distinct Phenotypes With Specific Signaling and Enhanced Survival.
Molecular & cellular proteomics : MCP - 1 Aug 2025
Nissen Paula, Popova Nadezhda V, Gocke Antonia, Smit Daniel J, Wong Geoffrey Yuet Mun, McKay Matthew J, Hugh Thomas J, David Kerstin, Juhl Hartmut, Voß Hannah, Marquardt Jens U, Nashan Björn, Schlüter Hartmut, Molloy Mark P, Jücker Manfred
Abstract excerpt
Colorectal carcinoma is a major global disease with the second highest mortality rate among carcinomas. The liver is the most common site for metastases which portends a poor prognosis. Nonetheless, considerable heterogeneity of colorectal cancer liver metastases (CRC-LM) exists, evidenced by varied recurrence and survival patterns in patients undergoing curative-intent resection. Our understanding of the basis...
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