Article

Link clustering explains non-central essential genes in protein interaction networks

2019-01-28

Abstract excerpt

Essential genes (EGs) often form central nodes in protein-protein interaction (PPI) networks. However, many reports have shown that numerous EGs are non-central, suggesting that another principle governs gene essentiality. We propose link clustering as a distinct indicator of the essentiality for non-central nodes. Specifically, in various human and yeast PPI networks, we found that 29 to 47% of EGs were better ch...

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Literature Corpus work: 6b6fd8e8-2ba6-56fa-8147-79faa28771b5
DOI: 10.1101/532770

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