Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene essentiality and the topology of protein interaction networks.

Proceedings. Biological sciences - 22 Aug 2005

Coulomb Stéphane, Bauer Michel, Bernard Denis, Marsolier-Kergoat Marie-Claude

Abstract excerpt

The mechanistic bases for gene essentiality and for cell mutational resistance have long been disputed. The recent availability of large protein interaction databases has fuelled the analysis of protein interaction networks and several authors have proposed that gene dispensability could be stron...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Gene Deletion
Share to Genes, Essential

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Interaction Mapping

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16087428
DOI: 10.1098/rspb.2005.3128
PMCID: PMC1559853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16087428-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene essentiality and the topology of protein interaction networks.PMID 16087428Read ↗

Link clustering explains non-central essential genes in protein interaction networksSemantic proximity Read ↗

Essentiality is an emergent property of metabolic network wiring.Semantic proximity Read ↗

Localized network centrality and essentiality in the yeast–protein interaction networkSemantic proximity Read ↗

Co-occurrence of essential gene dispensability and bypass suppressor mutations across speciesSemantic proximity Read ↗

The modifiers that cause changes in gene essentiality.Semantic proximity Read ↗

High-dimensional single-cell phenotyping reveals extensive haploinsufficiency.Semantic proximity Read ↗

ELIMINATOR: Essentiality anaLysIs using MultIsystem Networks And inTeger prOgRammingSemantic proximity Read ↗

Wrestling with pleiotropy: genomic and topological analysis of the yeast gene expression network.Semantic proximity Read ↗

Critical nodes reveal peculiar features of human essential genes and protein interactomeSemantic proximity Read ↗

Identifying essential genes across eukaryotes by machine learningSemantic proximity Read ↗

The role of protein interactions in mediating essentiality and synthetic lethality.Semantic proximity Read ↗

Functional and evolutionary inference in gene networks: does topology matter?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.