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Decrowding Expansion Pathology: Unmasking Previously Invisible Nanostructures and Cells in Intact Human Brain Pathology Specimens

2021-12-07

Abstract excerpt

Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy (ExM) variants have been used to separate proteins from each other in preserved biospecimens, improving antibody access to epitopes. Here we present an ExM variant, decrowding expansion pathology (dExPath), which can expand proteins away from each other in human brain pathology specimens, including formal...

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Literature Corpus work
6b6ce50c-7e10-5dea-922a-bac488345ffb
DOI
10.1101/2021.12.05.471271
Open publication

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Decrowding Expansion Pathology: Unmasking Previously Invisible Nanostructures and Cells in Intact Human Brain Pathology SpecimensDOI 10.1101/2021.12.05.471271
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