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Article

Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas.

Journal of hematology & oncology - 26 May 2025

Xu Ziyan, Wang Yunzhi, Xie Tao, Luo Rongkui, Ni Heng-Li, Xiang Hang, Tang Shaoshuai, Tan Subei, Fang Rundong, Ran Peng, Zhang Qiao, Xu Xiaomeng, Tian Sha, He Fuchu, Yang Wenjun, Ding Chen

Abstract excerpt

The spatial proteomic profiling of complex tissues is essential for investigating cellular function in physiological and pathological states. However, the imbalance among resolution, protein coverage, and expense precludes their systematic application to analyze whole tissue sections in an unbiased manner and with high resolution. Here, we introduce panoramic spatial enhanced resolution proteomics (PSERP), a...

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Identifiers

PMID: 40420200
DOI: 10.1186/s13045-025-01710-5
PMCID: PMC12107887

Genes

IDH1
EGFR
PDC

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