Competitive assembly resolves the stoichiometry of essential proteins in infectious HIV-1 virions

Abstract excerpt

During assembly on the plasma membrane, HIV-1 virions incorporate Gag-Pol as well as gp120/gp41 trimers. The Pol region consists of protease, reverse transcriptase and integrase precursors which are essential enzymes required for maturation, reverse transcription, and integration of the viral genome in the next host. gp120/gp41 trimers catalyze the fusion of the virion with its next host. Only a fraction of releas...

Topics

Open a Topic to create a Post that cites this publication.

• Bacteriophages and microbial interactions
• Capsid Proteins
• HIV Research and Treatment
• Monoclonal and Polyclonal Antibodies Research
• Protein Interaction Domains and Motifs
• RNA and protein synthesis mechanisms
• vaccines and immunoinformatics approaches
• Viral gastroenteritis research and epidemiology

Identifiers and source

Literature Corpus work

6b2ad85b-829e-5a4a-8677-4e95675a88c4

DOI

10.1101/2024.03.10.584319