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Article

Autocrine small extracellular vesicles induce tubular phenotypic transformation in diabetic nephropathy via miR-21-5p.

Gene - 20 Feb 2025

Zhang Mengting, Lu Yukang, Wang Lanfeng, Mao Yiping, Hu Xinyi, Chen Zhiping

Abstract excerpt

BACKGROUND: Diabetic nephropathy (DN) is one of the most common and serious microvascular complications associated with diabetes. DN is the leading contributor to the majority of cases of end-stage renal disease (ESRD). Small extracellular vesicles (sEVs) can transport various genetic materials to recipient cells. The objective of this study was to explore how sEVs released from HK-2 cells when stimulated by high...

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Identifiers

PMID: 39653091
DOI: 10.1016/j.gene.2024.149156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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