Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish

Abstract excerpt

Zebrafish models are well established tools for investigating underlying mechanisms of diseases. Here, we identified cercosporamide, a metabolite from the fungus Ascochyta aquiliqiae , as a potent bone morphogenetic protein (BMP) type I receptor kinase inhibitor through a zebrafish embryo phenotypic screen. The developmental defects in zebrafish, including lack of the ventral fin induced by cercosporamide was str...

Topics

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• Activin Receptors, Type I
• Bridged Bicyclo Compounds, Heterocyclic
• Dose-Response Relationship, Drug
• Molecular Structure
• Myositis Ossificans
• Protein Kinase Inhibitors
• Pyrazoles
• Structure-Activity Relationship

Identifiers and source

Literature Corpus work

6ae3eb80-c999-56f8-a1d1-e68ae395b86d

DOI

10.1101/2020.05.29.123588