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Article

Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model.

Oral diseases - 1 Apr 2023

Mukai Tomoyuki, Akagi Takahiko, Hiramatsu Asano Sumie, Tosa Ikue, Ono Mitsuaki, Kittaka Mizuho, Ueki Yasuyoshi, Yahagi Ayano, Iseki Masanori, Oohashi Toshitaka, Ishihara Katsuhiko, Morita Yoshitaka

Abstract excerpt

OBJECTIVE: Cherubism is a genetic disorder characterised by bilateral jawbone deformation. The associated jawbone lesions regress after puberty, whereas severe cases require surgical treatment. Although several drugs have been tested, fundamental treatment strategies for cherubism have not been established. The effectiveness of imatinib has recently been reported; however, its pharmaceutical mechanism remains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34743383
DOI: 10.1111/odi.14073
PMCID: PMC9076755

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