Article
Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development.
The Journal of biological chemistry - 18 Jul 2008
Granero-Moltó Froilán, Sarmah Swapnalee, O'Rear Lynda, Spagnoli Anna, Abrahamson Dale, Saus Juan, Hudson Billy G, Knapik Ela W
Abstract excerpt
Human Goodpasture antigen-binding protein (GPBP) is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen IV. The COL4A3BP gene is alternatively spliced producing two protein isoforms: GPBP and GPBPDelta26. The latter lacks a serine-rich domain composed of 26 amino acid residues. Both isoforms also function as ceramide transfer proteins (CERT). Here, we explored...
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