Article

Aptamer-Antibody Hybrid ELONA That Uses Hybridization Chain Reaction to Detect EN2, A Urinary Biomarker for Bladder and Prostate Cancer

2022-02-15

Abstract excerpt

We report an EN2-specific ( K d = 8.26 nM) aptamer, and a sensitive and specific enzyme-linked oligonucleotide assay (ELONA) for rapid and sensitive colorimetric detection of bladder and prostate cancer biomarker EN2 in urine. The assay relies on an aptamer-mediated hybridization chain reaction (HCR) to generate DNA nanostructures that bind to EN2 and simultaneously amplify signals. The assay can be performed with...

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Literature Corpus work: 6abb91ff-f908-50b9-8526-6f274eaa6d52
DOI: 10.21203/rs.3.rs-1304814/v1

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